The body’s ability to produce and metabolize CoQ-10 has been reported to decrease with age. CoQ-10 deficiency may be caused by insufficient dietary intake of CoQ-10, impairment in CoQ-10 production, drug-induced CoQ-10 depletion, gene mutations, and oxidative stress. HMG-CoA reductase is an enzyme required for the synthesis of cholesterol and CoQ-10. Cholesterol-lowering medications inhibit this enzyme in order to reduce cholesterol synthesis, but may also simultaneously deplete CoQ-10 status. In the event of CoQ-10 depletion, supplementation can improve CoQ10 status and help maintain optimal levels in the body.
Oxidative stress is a condition that occurs when there is an imbalance between free radicals and the antioxidants required to neutralize them, leading to oxidative damage in the body. The extent of oxidative stress depends on the rate of free radical generation, the level of antioxidant reserves and the rate of repair of cellular and tissue damage. This process has a significant impact on the body’s aging process. In its role in electron transport, CoQ-10 continuously goes through an oxidation-reduction cycle in order to neutralize free radicals and provide significant protection against toxic oxidative reactions in the body.
CoQ-10 is important for all energy-dependent processes, and is especially helpful in strengthening contraction of the heart muscle. CoQ-10 is also important for protection against free radical damage to the arterial vessels.